In SCAD cases with significant inflammation,there was abundant CD68+ staining throughout the adventitial infiltrate, extending intothe perivascular adipose tissue and in the media surrounding the dissection plane andhaematoma (Figure 1D).Similarly, there was significant, albeit less pronounced staining for CD3, whichappeared to be more spatially localized over the adventitial border of the vascularwall, as well as the outer rim of the media and adventitial inflammatory infiltrate(Figure 1E). This evidence concerns the gene CD68 and spontaneous coronary artery dissection.