Interestingly, most of these are well-studied pathways: cancer pathway (32 out of 328 genes), p53 signaling pathway (8 out of 69 genes), MAPK signaling pathway (21 out of 267 genes), WNT signaling pathway (12 out of 151 genes), and Jak-STAT signaling pathway (9 out of 155 genes) (S1 Fig). This evidence concerns the gene TP53 and cancer.