In human epidermal growth factor receptor 2‐positive breast cancer cell lines, free tRNALeu may interact with human epidermal growth factor receptor 3 (ErbB3) and binding protein (EBP1), which in turn activates the ErbB2/ErbB3 signaling pathways, and ultimately promotes cancer cell proliferation.33 This evidence concerns the gene ERBB3 and breast carcinoma.