STAT3 and cancer: STAT3 was also shown to encounter tumour suppressive effects in other types of tumours including papillary thyroid carcinoma [147], glioblastoma [148], in colon carcinoma STAT3 suppresses the development of ApcMin cancer possibly through the downregulation of Snail-1, suppressing an epithelial-mesenchymal transition of colorectal cancer cells [149, 150].