While earlier reports demonstrated that recombinant human IL-11 protects from hepatocyte damage induced by oxidative stress, drugs, or ischemia/reperfusion [51–54], more recent reports show that IL-11 rather promotes liver damage via ROS production [20], activates HSCs [19, 20], and hence, promotes liver fibrosis in the setting of chronic liver disease. The gene discussed is IL11; the disease is Hepatic fibrosis.