The staining scores presented positive correlations with clinical TNM stage (Kendall’s τ-b = 0.40, p = 2.22e-08) and histopathological grade (Kendall’s τ-b = 0.42, p = 1.23e-07), suggesting that TNS3 may facilitate the tumorigenesis of ESCC (Figure 4D). Here, TNS3 is linked to esophageal squamous cell carcinoma.