When mice were injected i.p. with anti-IFNAR1 antibody on the day of HSV-2 inoculation, disease progression was more rapid compared to isotype control-treated animals (Figure 4—figure supplement 1A), and the mice succumbed to infection at a faster rate (Figure 4—figure supplement 1B), in a manner similar to IFNAR1-deficient mice (Iversen et al., 2010; Iversen et al., 2016; Lee et al., 2017; Reinert et al., 2012; Wang et al., 2012). Here, IFNAR1 is linked to infection.