IFNAR1 and infection: IFNAR1-deficient mice are highly susceptible to HSV, regardless of the route of inoculation (Gill et al., 2006; Iversen et al., 2010; Iversen et al., 2016; Reinert et al., 2012; Royer et al., 2019; Svensson et al., 2007; Wilcox et al., 2016), and rapidly succumb to infection, mainly due to a loss of viral control.