However, unlike the LCMV model, early blockade of type I IFN signaling led to more severe disease and a complete loss of viral control after HSV-2 infection, similar to infections performed on an IFNAR1-deficient genetic background (Iversen et al., 2010; Iversen et al., 2016; Lee et al., 2017; Leib et al., 1999; Reinert et al., 2012; Wang et al., 2012), indicating an early antiviral role (Lee et al., 2017; Luker et al., 2003). This evidence concerns the gene IFNAR1 and infection.