In summary, our study showed reduced miR‐92b‐3p amount in exosomes form ovarian cancer cells, exosomal miR‐92b‐3p inhibits tumor growth and tumor‐related angiogenesis via targeting SOX4, and artificially generated exosomes with overexpressed miR‐92b‐3p (RGD‐SKOV3‐92b/exo), whether alone or combined with Apatinib, exert a strong inhibition of tumor growth via anti‐angiogenesis in vivo. Here, SOX4 is linked to ovarian carcinoma.