In our study, it was found that SOX4 was directly bound to miR‐92b‐3p by gene function experiments, revealed the opposite effect as miR‐92b‐3p on angiogenesis, and further, upregulated SOX4 partially reversed the decreased angiogenesis induced by upregulated miR‐92b‐3p, suggesting that exosomal miR‐92b‐3p modulates angiogenesis via targeting SOX4 in ovarian cancer cells. This evidence concerns the gene SOX4 and ovarian carcinoma.