Second, since various causes of HCC, such as HBV infection, hepatitis C virus infection, alcoholic liver disease, non‐alcoholic steatohepatitis, environmental and dietary carcinogens factors could contribute to the development and progression of HCC, the mechanism of COMMD10 in regulating different types of HCC might make a great difference. This evidence concerns the gene COMMD10 and hepatocellular carcinoma.