Orbital and pretibial fibroblast has been speculated as targets of the autoimmune process in ophthalmopathy and dermopathy, supported by the presence of thyrotropin receptor (TSH‐R) immunoreactivity in the dermal and orbital fibroblasts and identification of the thyrotropin receptor antibody (TRAb)‐binding sites in the plasma membranes of fibroblasts.8, 9, 10. This evidence concerns the gene TSHR and Abnormality of the skin.