IL6 and infection: Similar to the data in siRNA knockdown cells, we observed enhanced expression of Ifnb1, Il6, and Ifna4 mRNA and production of IFN‐β and IL6 protein in peritoneal macrophages prepared from Mettl14+/− mice upon infection with SeV, Encephalomyocarditis virus (EMCV), or simulation with 5′‐pppRNA, compared to that from wild‐type littermates (Figure 1C).