Western blotting analysis showed that SeV infection in WT macrophages increased the protein level of RIG‐I and MDA5 (Figure2A), whose increased expression after virus infection has been reported previously.[23] While, the protein level of MAVS, TBK1, and IRF3 is not greatly changed upon virus infection in WT macrophages (Figure 2A). The gene discussed is IRF3; the disease is viral infectious disease.