IFNB1 and viral infectious disease: One study showed that attenuating m6A writer METTL3 and reader YTHDF2 could directly reduce the m6A modification of mouse Ifnb1 mRNA, thereby accelerating its mRNA degradation, which decreased ISGs expression and weakened antiviral effect during viral infection.[20] It was also reported that knockdown of METTL14 using siRNA increased the production and stability of nascent Ifnb1 mRNA, consequently inhibiting the propagation of DNA virus, and increasing the yield of Ifnb1 mRNA induced by dsDNA or HCMV.