IFNB1 and hepatitis B virus infection: By comparison, knockout of ALKBH5 reduced the output of primary Ifnb1 mRNA, but did not significantly affect the degradation rate of Ifnb1 mRNA.[26] It was shown that HMPV RNAs were m6A methylated and that m6A methylation restrained the binding efficiently of viral RNA to RIG‐I, which inhibited IFN expression and promoted HMPV replication.[27] It was also reported that m6A modification of viral transcripts inhibited viral RNA recognition by RIG‐I and regulated host innate immunity against hepatitis B and C viral infections by inducing.[28]