As expected, MCA occlusion led to a significant reduction of cortical CBF in both stroke groups (Stroke-Ctrl: 78.17 ± 5.74 %; Stroke-HIF-1 LoF: 76.51 ± 4.69 %; Supplementary Fig. 1) as well as in additional tamoxifen/oil treated SMMHC-CreERT2 controls (Stroke-Oil: 79.00 ± 5.08 %; Stroke-TAM: 80.00 ± 2.29 %; Supplementary Fig. 1). This evidence concerns the gene HIF1A and stroke disorder.