In particular, polymorphisms in ANK3 that is involved in neurogenesis and in maintaining axonal structure on brain integrity, and in ZNF804A, which encodes a zinc finger protein, involved in neurodevelopment and myelin transcription have been associated with BD, and abnormal WM integrity in BD (Squarcina et al. 2017; Gurung and Prata 2015). The gene discussed is ZNF146; the disease is Behcet disease.