CD4 and Behcet disease: Specifically, research on offspring of BD patients suggests that BD could be characterized by a temporal dynamic changes of the immune state: increased proinflammatory state during adolescence, an anti-inflammatory state during young adulthood and a virtually normalized immune state at adulthood suggesting a partial T cell defect i.e. reduced numbers of CD3+ T cells and CD3+CD4+ T helper cells, leading to the deregulated immune system.