To further elucidate an oncogenic impact of FGFR1 and/or FGFR3 on EPN cell aggressiveness, we transduced ST-RELA and PF-A cell models, as well as the FGFR3-driven HCC Hep3B and the FGFR1-driven NSCLC NCI-H1703 cell lines (all grown under adherent conditions) with a kinase-truncated, dominant-negative FGFR1-IIIc (dnFGFR1) or a kinase-dead FGFR3-IIIc (dnFGFR3) adenoviral construct, comparing effects to a green fluorescent protein (GFP)-expressing control virus. Here, FGFR3 is linked to non-small cell lung carcinoma.