The thyroid color doppler ultrasound of Proband A indicated mild diffuse enlargement of the thyroid gland with clear boundaries and no space occupation; however, the thyroid peroxidase and TG antibodies were elevated, resulting in a diagnosis of “Hashimoto's thyroiditis.” In addition, the electronic gastroscope showed chronic superficial gastritis, and proton pump inhibitors were administered for treatment. Here, TPO is linked to Hashimoto thyroiditis.