This information, combined with the color Doppler ultrasound results, and the elevated thyroid peroxidase and TG antibodies, evoked a diagnosis in both of “Hashimoto's thyroiditis (HT).” In the literature review of 18 cases of AITD combined with GS, 13 cases had toxic diffuse goiter (Graves' disease, GD), 3 cases had HT, 2 cases were positive for the simple AITD antibody, and 1 case was a base deletion mutation; the rest were single base substitutions [20]. This evidence concerns the gene TPO and toxic diffuse goiter.