Although the exact cellular mechanisms by which CBD exerts its effects remain unclear (Ibeas Bih et al., 2015), one potential mechanism may relate to its ability to interact with the voltage-dependent anion channel 1 (VDAC1) (Rimmerman et al., 2013), which is central to metabolic reprogramming, apoptosis, and a cancer drug target (Shoshan-Barmatz et al., 2018). Here, VDAC1 is linked to cancer.