Functionally, METTL14 was regarded to structurally stabilize METTL3 conformation and help substrate recognition (Wang et al., 2016) Decreased expression of METTL14 was seen in HCC and was correlated with migration, invasion and EMT of HCC cells (Shi et al., 2020). The gene discussed is METTL14; the disease is hepatocellular carcinoma.