In summary, Knockdown of METTL3 probably reversed the increasing transcription efficiency of FOXO3 mediated by YTHDF1 and brought about decreased FOXO3 expression, thus facilitating transcription of genes related to autophagy including ATG3/5/7/12, ATG16L1, and MAP1LC3B in HCC, ultimately leading to resistance of sorafenib (Lin Z. et al., 2020). The gene discussed is FOXO3; the disease is hepatocellular carcinoma.