RDM1 and cancer: Decreased expression of RDM1 was noticed to be related to stimulated calcium signaling which contributed to cancer cell survival, together with activated KRAS and RAF pathways which, as upstream of MEK/ERK pathways, enhanced cancer cell growth, survival and metabolism (Chen S. L. et al., 2020) (Asati et al., 2016; Reczek and Chandel, 2018).