Increased level of autophagosomes and LC3 were also observed in sorafenib-resistant HCC, and could be reversed by overexpression of wild-type METTL3, indicating that autophagy process may be associated with METTL3 and responsible for sorafenib-resistance (Lin Z. et al., 2020). This evidence concerns the gene METTL3 and hepatocellular carcinoma.