Plasma levels of PGRN and CysC were partially altered, and specifically PGRN was reduced in FTD while CysC was increased in DLB; however, taking together all variables significantly associated with the diagnostic groups, including PGRN and CysC, only the two parameters related to EVs, i.e., EVs concentration and EVs size, were able to distinguish patients from controls. This evidence concerns the gene GRN and Lewy body dementia.