MAPT and Alzheimer disease: Other studies in blood-derived EVs demonstrated an alteration of their cargo in AD, and specifically increased levels of Aβ and tau/p-tau181 (Fiandaca et al., 2015), a dysregulation of a panel of miRNA (Serpente et al., 2020), and a reduction of survival factors (Goetzl et al., 2015, 2016, 2018).