Thus, EVs, and specifically exosomes, have been suggested as potential carriers of misfolded toxic proteins, such as Aβ peptide and tau in AD (Saman et al., 2012; Rajendran et al., 2014) and α-synuclein in Parkinson disease (PD)/DLB (Emmanouilidou et al., 2010; Alvarez-Erviti et al., 2011). The gene discussed is MAPT; the disease is Alzheimer disease.