SOX2 and metastatic malignant neoplasm in the lymph nodes: When comparing liver metastases to lymph node metastases for the investigated genes, PTPN13 (p = 0.012), ZEB2, RND3, CDKN1B (p = 0.036) were down-regulated, while ONECUT2 (p = 0.046), TGFB2, SOX2 were up-regulated in the liver metastases as shown in Figure 4.