AKR1C1 and malignant colon neoplasm: In the HPA database, we found that the expression of AKR1C1, ALOX12, and CARS1 in colon cancer tissue is higher than normal tissue (Figures 6A–C) and the expression of FDFT1 in colon cancer tissue is lower than normal tissue by immunohistochemistry (Figure 6D), which is consistent with our results.