Recently, researches highlighted the crucial mediator of CXCR6 and signal transducer and activator of transcription 3 (STAT3) pathway, which suggest a prominent production of CXCL16 in MSC via the activation of Wnt5a/Ror2 signaling axis, in turn, activates its corresponding receptor CXCR6 to increase the expression of Ror1 via the activation of STAT3, eventually resulting in the promotion of proliferation and migration of GC cells (39, 40). This evidence concerns the gene STAT3 and gastric cancer.