Emerging research spots that the immunophenotype of GC-MSC are also influenced by the CD4 T cells via the p-STAT3 signaling pathway to boost cancer growth rate-promoting role of GC-MSCs, highlighting that TME is a huge complicated signaling network in which tumor cells, immune cells, MSC and other components are in a multi-angle communication to facilitate cancer progression (63). The gene discussed is STAT3; the disease is neoplasm.