Mirroring macrophages, the IL-6 enriched in the GC-MSC-CM can stimulate the phosphorylation of STAT3 and ERK1/2 in neutrophils, promoting their recruitment and activation into a pro-tumor phenotype that would finely cooperate with GC-MSC to synergistically prompt cancer migration and angiogenesis (34). This evidence concerns the gene STAT3 and cancer.