The stage I/II ccRCC samples showed an increase in the expression of CA9, NDUFA4L2, HIG2, INHBB, IGFBP3, ANGPTL4, EGLN3, VWF, TYROBP, BHLHE41, STC2, NNMT, SLC16A3, C1QA, and CD36 relative to normal kidney tissue. Here, IGFBP3 is linked to nonpapillary renal cell carcinoma.