The analysis of GO processes associated with the genes whose levels of expression are not altered during tumor progression (HIG2, INHBB, TYROBP, STC2, CXCR4, NNMT, FN1, PFKP, SLC16A3, C1QA, and CD36) indicates that these genes are activated in the initial phase, and maintained at all stages of development of ccRCC metabolic and inflammatory processes and positive regulation of the multicellular organismal process. This evidence concerns the gene NNMT and neoplasm.