The stage I/II ccRCC samples showed an increase in the expression of CA9, NDUFA4L2, HIG2, INHBB, IGFBP3, ANGPTL4, EGLN3, VWF, TYROBP, BHLHE41, STC2, NNMT, SLC16A3, C1QA, and CD36 relative to normal kidney tissue. The gene discussed is VWF; the disease is nonpapillary renal cell carcinoma.