The stage I/II ccRCC samples showed an increase in the expression of CA9, NDUFA4L2, HIG2, INHBB, IGFBP3, ANGPTL4, EGLN3, VWF, TYROBP, BHLHE41, STC2, NNMT, SLC16A3, C1QA, and CD36 relative to normal kidney tissue. This evidence concerns the gene COXFA4L2 and nonpapillary renal cell carcinoma.