IGFBP3 and neoplasm: These processes include the transition to glycolysis and the corresponding decrease in oxygen consumption by mitochondria (EGLN3, NDUFA4L2, and, apparently, IGFBP3); the maintenance of acid-base balance (CA9), shifted due to glycolysis; stimulation of tumor growth; and prevention of apoptotic cell death in difficult adaptation conditions (BHLHE41, VWF, and possibly IGFBP3, and ANGPTL4).