At the initial stage of tumor development, the activation of the genes under consideration provides adaptation to hypoxia, accompanied by a metabolic shift, i.e., the development of glycolysis and a decrease in oxidative phosphorylation (EGLN3, NDUFA4L2, ANGPTL4, CA9, and, apparently, IGFBP3). Here, IGFBP3 is linked to neoplasm.