IGFBP3 and neoplasm: Its activation in the tumor at this stage correlates with the expression levels of the other HIF-1-induced genes studied, i.e., CA9, NDUFA4L2, EGLN3, and IGFBP3. Such coordination of gene expression indicates that their functions are associated with the processes of energy metabolism, that is connected to the above-mentioned participation of ANGPTL4 in glucose metabolism.