SOD2 and Hyperglycemia: Our data demonstrated that treatment of HepG2 cells with D-glucose evoked a notable increase in SOD activity, and quercetin significantly counterbalancedit, which is compatible with the study of Ceriello et al. showing that hyperglycemia increased the activity and mRNA expression of Cu, Zn-SOD and Mn-SOD in human endothelial cells (Ceriello et al., 1996 ▶).