A prospective study performed using a 44 gene panel testing including patients with breast cancer, colorectal cancer, and other early-onset cancers who have tested negative for pathogenic genes including BACA1/2 showed that 5% of the study population carried pathogenic or highly pathogenic variants of moderate to high penetrance genes like BRCA2, MSH6, CHECK2, ATM, and MUTYH and 87 VUS. The gene discussed is MSH6; the disease is colorectal cancer.