For instance, increased levels of Lipocalin 2 were seen at active phases, onset and relapse, in blood-CSF sample as well as choroid plexus (CP) of EAE mice [95]; however, administration of Natalizumab, a well-known medication for MS [96], ameliorated the severity of EAE by modulating and normalizing CSF Lipocalin 2, while markedly reducing its astrocytic expression. The gene discussed is LCN2; the disease is myeloid sarcoma.