Reclassification analyses demonstrated that addition of NT-proBNP to HFRV improved NRI by 23.1% (p=0.07; pevents=0.53; pnon-events<0.001) in those with CKD and by 10.2% (p=0.003; pevents=0.01; pnon-events<0.001) in those without CKD while the addition of eGFR to HFRV changed the NRI by 6.53% (p=0.09; pevents=0.16; pnon-events=0.25) and −0.46% (p=0.72; pevents=0.65; pnon-events=0.45) in the CKD and non-CKD groups, respectively. The gene discussed is NPPB; the disease is chronic kidney disease.