The lncRNA TUG1 acts as a sponge for miR-1299 and promotes cell proliferation by upregulating NOTCH3. TUG1 is also a potential target for NOTCH3, forming a miR-1299/NOTCH3/TUG1 feedback loop to regulate the proliferation and apoptosis of ovarian cancer cells. The gene discussed is TUG1; the disease is ovarian cancer.