On the other hand, the researchers found by real-time PCR that the expression of miR-1299 was negatively correlated with the expression of STAT3 in colon cancer tissue: overexpression of miR-1299 can significantly inhibit the expression of STAT3, and when the expression of miR-1299 decreases, the expression of STAT3 increases, which is further evidence that miR-1299 can regulate STAT3. Annexin V-FITC staining showed that apoptosis of colon cancer cells was stimulated when miR-1299 was overexpressed. The gene discussed is STAT3; the disease is malignant colon neoplasm.