EGFR and esophageal squamous cell carcinoma: At the same time, the EGFR mRNA expression level detected by qRT-PCR showed that, miR-1299 significantly reduces the expression of EGFR. miR-1299 has a binding sequence in the 3′-UTR of EGFR that regulates the downstream Akt-mTOR pathway, thereby promoting the autophagy of ESCC cells.