CDK6 and hepatocellular carcinoma: Researchers also found that the cell cycle regulator CDK6 is a target of miR-1299, and that miR-1299 can bind to the 3′-UTR of CDK6. The simultaneous downregulation of CDK6 and miR-1299 increased the proliferation ability of HCC cells, indicating that miR-1299 inhibits the proliferation of HCC cells by downregulating the expression of CDK6.