The lncRNA TUG1 acts as a sponge for miR-1299 and promotes cell proliferation by upregulating NOTCH3. TUG1 is also a potential target for NOTCH3, forming a miR-1299/NOTCH3/TUG1 feedback loop to regulate the proliferation and apoptosis of ovarian cancer cells. This evidence concerns the gene NOTCH3 and ovarian carcinoma.