Logistic regression analysis revealed that the level of insulin ≥22.7, TNF-α ≥3.9, AGEs ≥11.6, creatinine ≥1.1 were the significant predicting factors for DM-DD from DM-N with adjusted odds ratio (AOR) 13.8, 4.9, 6.9 and 7.8, respectively; p < 0.05. This evidence concerns the gene TNF and diabetes mellitus.