IL4 and inflammatory bowel disease: Inflammatory bowel disease (IBD, including ulcerative colitis) is a chronic gastrointestinal disorder caused by inflammation or oxidative stress in the colon, which has threatened the human health and has various colitis symptoms, such as gut bleeding, bloody diarrhea, body weight (BW) loss, epithelial cell loss, neutrophil infiltration, and the release of proinflammatory mediators (e.g., interleukin- (IL-) 1β, IL-4, IL-5, IL-6, IL-8, and tumor necrosis factor- (TNF-) α) [1].