Intriguingly, it was recently reported that lncRNAs (TROLL-2 and TROLL-3) could counteract the interaction between WDR26 and NOLC1, while promoting the combination of WDR26 and AKT to activate the PI3K/AKT pathway in lung cancer cells, human breast carcinoma cells, and human melanoma cell lines [16]. Here, PIK3CA is linked to melanoma.