Chemokines CXCL13, CCL19, CCL8, CXCL8, CXCL16, MMP9, CCL18, CXCL5, VCAM1, and PPBP were identified as the hub genes of CAVD. This evidence concerns the gene CXCL13 and congenital bilateral aplasia of vas deferens from CFTR mutation.