To explore molecular mechanism of CAVD, ten hub genes (CXCL13, CCL19, CCL8, CXCL8, CXCL16, MMP9, CCL18, CXCL5, VCAM1, and PPBP) connected with CAVD occurrence were explored out based on the STRING and Cytoscape software. Here, PPBP is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.