SH2B1 and Down syndrome: For individuals negative for this streamlined testing with phenotypes similar to PWS with obesity, an expanded panel of genes can be considered to test diseases recognized as syndromic obesity syndromes, such as Alstrom, Bardet–Beidel, Cohen, Carpenter, Kabuki, WAGR, or Fragile X, or monogenic causes (e.g., LEP, LEPR, BDNF, FTO, SH2B1, POMC, MCR4, TUB, AGRP, UCP1, CART, NEGR1, and PPARG) (e.g., Bell et al., 2005; Choquet and Meyre, 2010; Butler, 2016; Kaur et al., 2017).