However, LBR5, LBR6 and LBR8 induced increased levels of pro-inflammatory cytokines (IFN-γ, IL-2, IL-6, TNF-α and IL-17A), which are consistent with a robust Th1 immune response that especially promotes cellular proliferation and the formation of granulomas (IFN-γ and TNF-α) (22, 24, 49). This evidence concerns the gene TNF and Granuloma.