The APP/Arg1 sufficient mice had increased transcriptomic pathway scores than nTg/Arg1 sufficient mice in autophagy (p = 0.001, Figure 2F), activated microglia (p = 0.010, Figure 2H), AD causal risk pathway (p = 0.002, Figure 2C), neuronal cytoskeleton (p = 0.006, Figure 2E), disease association (p = 0.041, Figure 2D), and myelination (p = 0.003, Figure 2L) (Figure 6D). Here, APP is linked to Alzheimer disease.