APP and Alzheimer disease: Comparing APP mice (APP+/-/LysMcreTg/+) to nTg mice (nTg/LysMcreTg/+), the top eight up-regulated transcriptomic pathways were AD causal risk pathway (GSS = 2.922), activated microglia (GSS = 2.665), autophagy (GSS = 2.497), neuronal cytoskeleton (GSS = 2.442), cytokines (GSS = 2.044), angiogenesis (GSS = 1.806), myelination (GSS = 1.699), and disease association (GSS = 1.575) (Figure 3B).