PPARGC1A and metabolic dysfunction-associated steatotic liver disease: Nevertheless, TF binding motif analysis of NAFLD differentially methylated sites revealed strong enrichments for binding motifs of bona fide hepatic regulators of glucose and lipid metabolism such as PGC1α, SREBF2, FOXA1, and FOXA2 (48), further supporting the notion that appropriate DNA methylation is necessary for overall hepatic metabolic homeostasis.