These have identified CpG sites at which differential methylation associated with measures of insulin sensitivity and future risk of T2D, including at SREBF1 (69), which encodes the sterol regulatory element binding transcription factor 1 (SREBF1, also known as SREBP-1), a recognised regulator of insulin action in the liver (88) (Figure 2). This evidence concerns the gene SREBF1 and type 2 diabetes mellitus.