PPARGC1A and metabolic dysfunction-associated steatotic liver disease: Following the established link between IR and mitochondrial dysfunction in NAFLD (44), the authors investigated whether there was evidence of altered methylation at PPARGC1A, which encodes the peroxisome proliferator-activated receptor gamma coactivator 1α (PGC1α), a fasting-induced transcriptional coactivator that regulates mitochondrial biogenesis (45).