The reversal by CRF1 antagonism demonstrated that amygdalar CRF signaling was critical for this effect, consistent with its known role in pain in adults (Rouwette et al., 2012) including arthritis (Ji and Neugebauer, 2007; Neugebauer et al., 2020) and neuropathic pain (Andreoli et al., 2017). Here, CRHR1 is linked to arthritic joint disease.