Secondly, thrombin was reported as a critical mediator in LPS-induced liver damage (Rondina et al., 2011) and gut-derived-LPS through TLR4 activation was significantly involved in CCl4-induced liver fibrosis (Seki et al., 2007; Rondina et al., 2011; Wang et al., 2020). The gene discussed is TLR4; the disease is Hepatic fibrosis.