The extent of HSCs activation and proliferation rates is indicated by the expression of characteristic specific receptors such as α-SMA (Jiang and Torok, 2013; Lin et al., 2018) and excessive production of collagen, where the deposition of collagen fibrils in liver connective tissues provides a hallmark of liver fibrosis development (Hernandez-Gea and Friedman, 2011; Bai et al., 2013). Here, ACTA1 is linked to Hepatic fibrosis.