Besides increasing body weight and muscle body mass, α-ketoacid showed many protective effect on CKD individuals, including reducing proteinuria and histological damage of kidney (Gao et al., 2010), reducing phosphate and parathyroid hormone levels (Garneata et al., 2016; Di Iorio et al., 2018), and declining diastolic blood pressure (Di Iorio et al., 2018) when supplemented with protein restriction in CKD patients and nephrectomy animals. Here, PTH is linked to chronic kidney disease.