Moreover, Lee et al. indicated that zerumbone attenuates IL-1β production, inhibits MAPKs phosphorylation, decreases NF-κB activation, suppresses neutrophils infiltration, and inhibits the expression of adhesion molecules intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in an LPS-induced acute lung injury mouse model (Lee et al., 2018). Here, ICAM1 is linked to acute lung injury.