NLRP3 and central nervous system cancer: On the other hand, the activation of NLRP3 inflammasome and the expression of IL-1β are associated with cancer development, metastasis, and poor prognosis in several types of cancers, including breast (Jeon et al., 2016), lung (Wang et al., 2016), colorectal (Deng et al., 2019), and glioma (Yin et al., 2018), etc. Previous studies showed that zerumbone inhibits the expression of IL-β and suppresses IL-1β-induced cell migration and invasion in triple-negative breast cancer (Han et al., 2014; Jeon et al., 2016).