PTEN and Alzheimer disease: As such, we now know from cell and animal models that PTEN activity is required for NMDAR-dependent LTD and that Aβ facilitates this type of plasticity (Wang et al., 2006; Jurado et al., 2010; Sperow et al., 2012; Knafo et al., 2016; Knafo and Esteban, 2017; Sanchez-Puelles et al., 2020), establishing a potential link between PTEN and AD.