Sema7A has been detected in neurons close to MS lesions as well as in reactive astrocytes and oligodendrocytes in the damaged white matter in mice and human tissue (Costa et al., 2015; Gutiérrez-Franco et al., 2016), suggesting it may have an inhibitory role in compensatory axonal remodeling in lesioned areas. The gene discussed is SEMA7A; the disease is myeloid sarcoma.