Similarly, the expression of Sema3F protein in the dentate gyrus is decreased in a lithium-pilocarpine-induced status epilepticus mouse model, in parallel to mossy fiber sprouting occurring in that region, suggesting that reduced expression of Sema3F may facilitate anomalous growth of mossy fibers (Cai et al., 2016). The gene discussed is SEMA3F; the disease is status epilepticus.