In addition, by using RNA sequence data from AD patients and building a molecular network using modules of coexpressed genes, PlxnB1 gene has been found to be strongly correlated with β-amyloid burden as well as cognitive decline in older individuals, and with extracellular β-amyloid levels in astrocyte cultures (Mostafavi et al., 2018). This evidence concerns the gene PLXNB1 and Alzheimer disease.