On the contrary, a significant association between AD risk and SNPs in PlxnA4 has been recently identified, and higher levels of PlxnA4 isoforms in cortical brain tissue were observed in late stage AD cases compared to controls, which were significantly correlated with the clinical dementia rating score, plaque density, and Braak stage (Jun et al., 2014). This evidence concerns the gene PLXNA4 and Alzheimer disease.