SEMA3A and amyotrophic lateral sclerosis: Sema3A is upregulated in terminal Schwann cells at the NMJ in type IIb muscle fibers (which are innervated by fast-fatigable motoneurons) in pre-symptomatic ALS mice, suggesting that it may induce the retraction of these terminals from the neuromuscular synapse (de Winter et al., 2006).