IGHE and asthma: Scgb1a1-CreTg mice developed signs of asthma pathology that were indistinguishable from their Scgb1a1-CreWT littermates, as judged by histopathological analysis (Fig. S4B), BALF inflammatory cell quantitation (Fig. S4C), TH2 cytokine secretion by MLN cells (Fig. S4E) and serum IgE production (Fig. S4D).