RIPK3 and asthma: RIPK3 mediates necroptosis by phosphorylating and activating the downstream effector MLKL, however, RIPK3 has also been implicated in necroptosis-independent signaling.37,38 To directly assess the role of necroptosis in the exacerbated asthma-like pathology of FADDAEC-KO mice we generated FADDAEC-KOMlkl−/− mice (Fig. S3A) and subjected these mice and their littermate controls to the same protocol of sensitization and challenge with HDM.