Taken together, these results showed that the exacerbated lung inflammation in HDM-challenged FADDAEC-KO mice is specifically linked to the loss of FADD in AECs and depends on RIPK3, suggesting that increased necroptosis of FADD-deficient AECs contributes to the worsening of HDM-induced asthma. The gene discussed is RIPK3; the disease is asthma.