To study how AEC-specific FADD ablation affected the pathogenesis of allergic airway inflammation we analyzed the response of FADDAEC-KO mice and their Faddfl/fl littermates to a well-established model of asthma induced by instillation of HDM.15 To this end, mice were sensitized with intranasal instillation of 1 μg HDM on day 0 followed by challenge with 10 μg HDM on 5 consecutive days starting 1 week after sensitization. The gene discussed is FADD; the disease is asthma.