The present analyses also identified a number of recurrently mutated long genes, such as TTN, CSMD3, MUC16, LRP1B, and ZFHX4. However, gene length is one determinant of the probability of a mutation occurring in a given gene, and frequently mutated long genes have been reported for a wide range of tumour entities [48, 49]. The gene discussed is ZFHX4; the disease is neoplasm.