Multiple gene mutations have been found in patients with MDS and involve genes responsible for epigenetic regulation (TET2, ASXL1, EZH2, DNMT3A, and IDH1/2), RNA splicing (SF3B1, SRSF2, U2AF1, and ZRSR2), DNA damage response (TP53), transcriptional regulation (RUNX1, BCOR, and ETV6), signal transduction (CBL, NRAS, and JAK2), and the cohesion complex (STAG2) [16, 18]. This evidence concerns the gene U2AF1 and myelodysplastic syndrome.