Zorzoli et al.81 reported that IL-27 inhibits acute myeloid leukemia (AML) cell growth in an NSG mouse model by upregulating antiangiogenic genes such as IFNγ, CXCL10, and tissue inhibitors of metalloproteinase (TIMP)-2 and by downregulating genes involved in tumor spreading such as cadherin-6 (CDH6). This evidence concerns the gene CDH6 and acute myeloid leukemia.