The AUC of four scoring systems were compared with each other, LODS versus SAPS II (Z = 8.810, P < 0.0001), LODS versus SIRS (Z = 12.736, P < 0.0001), LODS versus SOFA (Z = 6.602, P < 0.0001), SAPS II versus SIRS (Z = 18.055, P < 0.0001), SAPS II versus SOFA (Z = 12.566, P < 0.0001), SIRS versus SOFA (Z = 7.924, P < 0.0001). The gene discussed is SKAP2; the disease is systemic inflammatory response syndrome.