The results of the AUC comparisons were as follows: LODS versus SAPS II (Z = 5.342, P < 0.0001), LODS versus SIRS (Z = 9.539, P < 0.0001), LODS versus SOFA (Z = 1.230, P = 0.2186), SAPS II versus SIRS (Z = 12.604, P < 0.0001), SAPS II versus SOFA (Z = 5.365, P < 0.0001), SIRS versus SOFA (Z = 8.058, P = 0.0010). The gene discussed is SKAP2; the disease is systemic inflammatory response syndrome.