Given that CCN1 is a critical factor for HSV-1 resistance, we investigated the dependencies of the genes in our prioritized subnetwork using the gene dependency datasets DEMETER2 (RNAi) and Avana (CRISPR) (Fig. 4a–c)32,33 to further dissect GBM cancer vulnerabilities. The gene discussed is CCN1; the disease is glioblastoma.