Two control subjects with hypertension and hypertrophic heart (4%) carried likely pathogenic variants; Gly853Argfs (c.2555dupT) in MYBPC3, and Arg219Ter (c.566C>T) in LDB3. These variants were classified as likely pathogenic due to their absence from, or a very low frequency in, the general population and predicted loss of function effect. Here, MYBPC3 is linked to Hypertension.