Fourteen proteins were found to be differentially expressed (Bonferroni’s corrected α = 3.8 × 10−5 for 1305 proteins measured) in intracellular HUVECs, whereas 48 proteins were found to exhibit a significant variation following TNFα stimulation in the presence of hyperglycemia in the extracellular HUVECs. Here, TNF is linked to Hyperglycemia.