TNF and diabetic kidney disease: Firstly, we further confirmed our previous observations in DKD that TNFα ligand effects were negligible on TNF receptors, and secondly, the use of highly multiplexed SOMAscan platform, and thirdly, we performed the first global proteomic analysis directly comparing the intracellular and the extracellular/secreted matrix proteome, in TNFα-stimulated HUVECs exposed to a hyperglycemic condition, allowing for a more detailed picture of the inflammatory processes in fraction-specific components.