TNF and Hyperglycemia: To analyze the biological context of differentially expressed proteins in intracellular and extracellular of TNFα-stimulated HUVECs in the presence of hyperglycemia, the list of 53 significant proteins (Fig. 4b, excluding KRIS proteins) were used as input for functional enrichment [over-representation of gene ontology (GO)] analysis using DAVID Bioinformatics database.