CCL2 and breast cancer: BC in the TCGA cohort were analyzed by CIBERSORT that showed tumors with high expression of all three cytokines CSF2, CXCL10, and CCL2 had significantly increased M1 macrophage polarization, decreased M2 macrophage polarization, and no change in the number of resting macrophages (M0) (Fig. 5c and Supplementary Fig. 8c).