TNF and Sepsis: However, the survival rate in leukocyte-specific Gα13-knockout mice was significantly lower than that in the MB2mP6-treated mice (Fig. 7a vs Fig. 5a and summarized in Supplementary Fig. 8, p < 0.05) Importantly, the elevation of serum cytokines IL-6 and TNFα levels 24 h after CLP were significantly inhibited in Gα13fl/fl-LysMCre mice (Fig. 7b, c), suggesting that leukocyte Gα13 plays a major role in the inflammatory state induced by sepsis.